Signed in as:
filler@godaddy.com
Signed in as:
filler@godaddy.com
History & Background:
Cannabitriol (CBT) is one of the minor cannabinoids found in the cannabis plant. CBT was first discovered in 1966 by Obata and Ishikawa, but its chemical structure was later determined by researchers in 1976. As of now, there are nine known types of CBT. CBT is not always present in cannabis, but when it is, its concentration is always very low. Because of this, it has been very difficult for scientists to extract and study. Although CBT is structurally similar to THC, it is unknown as to whether or not CBT has similar psychoactive effects.
Cannabicitran is also known as CBT-C. It was first synthesized in 1971 by Crombie and Ponsford. At the time, they named it citrylidene-cannabis. Then, in 1974, it was isolated from Lebanese hashish. As of now, the configuration of CBT-C is unknown. As well, in 1977, the C10-ethoxy derivative of CBT-C was successfully isolated.
Additional findings pointed out that CBT (Cannabicitran) is a cannabinoid that was discovered and isolated in 2019 by researchers at the University of Modena and Reggio Emilia in Italy. It was found that CBT is a non-psychoactive compound that is produced in very small amounts by some cultivars of cannabis plants.
CBT: Looking Deeper:
The rarity of the CBT cannabinoids made them fairly difficult to study in the past, but it was only through studying CBT that scientists came to realize that CBG wasn’t the only “stem cell” or “mother” cannabinoid in cannabis after all. Another fact that makes CBT a very special cannabinoid indeed is that it is actually produced by the CBC cannabinoid!
Each different type of CBT features a very small difference in its arrangement of atoms. The two types of CBT that have gained the most interest so far are cannabitriol and cannabicitran.
CBT is a CBC derivative, and so far, nine distinct forms of CBT have been discovered. One of these forms, cannabicitran (CBT-C) has received significant attention partially due to the fact that it’s one of the only cannabinoids that has also been found outside cannabis.
CBT In Cannabis:
CBT is one of the lesser-known cannabinoids found in cannabis. While most strains of cannabis contain higher concentrations of THC or CBD, some cultivars have been found to have slightly higher levels of CBT. However, due to the fact that CBT is produced in such small amounts by the plant, it has not received the same attention as other cannabinoids.
CBT And The Entourage Effect:
The entourage effect is the theory that the different compounds found in cannabis, including cannabinoids and terpenes, work together to enhance each other's effects. While THC and CBD are often considered the primary cannabinoids involved in the entourage effect, researchers believe that CBT and other lesser-known cannabinoids may also play a role.
Benefits Of CBT:
One study in 1983 showed that CBT effectively reduced intraocular eye pressure, so it may prove to be useful in the treatment of glaucoma, along with many other cannabinoids. In addition, early research has suggested that CBT may have the potential to help manage pain and anxiety.
A 2011 study also successfully isolated a substance from Chinese rhododendron that is chemically identical to CBT-C. Chinese rhododendron has been used in traditional Chinese medicine (TCM) for thousands of years to treat respiratory illnesses (asthma and bronchitis), joint pain, congestion, as well as for the prevention and treatment of diseases of the heart.
Another piece of research, published just last year in 2021, found that cannabitriol was also an effective estrogen receptor agonist. Much more research is needed to confirm their findings, but the team concluded that cannabitriol “could have relatively better inhibitory activity than tamoxifen (an estrogen modulator currently used to treat breast cancer) and could be a better and patent therapeutic candidate in the treatment of BC”.
CBT does not appear to have significant psychoactive effects, and one form of CBT, CBT-C, has been shown to mitigate the negative effects of THC.
CBT Is More Common In Hemp:
Researchers have noticed that CBT cannabinoids are more commonly found in type III cannabis strains (a term used to describe high-CBD, low-THC cannabis, AKA hemp) as opposed to type I cannabis strains (high-THC, low-CBD cannabis). So CBD flower, broad-spectrum, and full spectrum CBD products that are high in CBC are much more likely to have CBT in them than other cannabis products.
Cultivars (strains) With Higher-Than-Average Concentrations Of CBT: