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Bisabolol. noun. bisa·bol·ol ˈbisa-bȯl-ȯl -ˌōl. : a crystalline monocyclic alcohol C15H26O that occurs in two enantiomeric forms, is found in soap, and is used in the phama industry.
Alpha-bisabolol is an aromatic terpene that immerses a sweet floral aroma. Besides cannabis, it is found in chamomile and South African candela trees. The terpene is often referred to as a-bisabolol, levomenol, or simply bisabolol. Alpha-bisabolol is widely used in producing soaps, shampoos, and different types of cosmetic treatments for sensitive skin. It is also widely utilized in the pharma industry.
Just as different cannabinoids have different effects, so do terpenes. These unique attributes contribute to the overall composition of a strain, adding a dimension to each one’s “personality.” Though research is still substantiating ocimene effects and benefits, the following uses are currently being investigated:
Unlike primary terpenes (Myrcene, Linalool, Limonene), Alpha-bisabolol is found in cannabis in smaller amounts. Yet, it also has a wide range of positive effects. The terpene fights infections, reduces inflammation, and even stops the spreading of cancer cells (in lab settings). Alpha-bisabolol, just like CBD, supports the immune system and promotes relaxation. That’s why patients with insomnia, stress, depression, and anxiety benefit from using Alpha-bisabolol strains.
The anti-inflammatory usefulness of the terpene can not be underestimated as well. Alpha-bisabolol terpene strains seem to reduce the number of cytokines, proteins released by the immune system in response to the inflammation.
Cultivars (strains) with Bisabolol Dominance
Cautions
The active ingredients in chamomile include the volatile oils alpha-bisabolol and bisabolol oxide and the flavonoids apigenin, luteolin, and quercetin. Chamomile is generally safe, although patients allergic to ragweed, asters, or chrysanthemums should take chamomile with caution. Chamomile is a member of the daisy family and has contributed to allergic reactions in rare cases.
It is important to specify normal concentrations, as some terpenes can cause irritation, allergic reaction, nausea, headache, and/or acute toxic effects at very high doses - but these doses are much higher than you would ever consume in the course of using cannabis products.
Some terpenes can be dermal irritants, so their concentration in topical products needs to be carefully controlled. Guidance from organizations such as the International Fragrance Association shows that safe limits depend both on the type of product and the individual terpene.
The pharmacological hypothesis argues that aromatic compounds such as terpenes affect mood, physiology, and behavior because they interact with the nervous and/or endocrine systems (hormones).
Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, is a natural monocyclic sesquiterpene alcohol. It is a colorless viscous oil that is the primary constituent of the essential oil from German chamomile (Matricaria recutita) and Myoporum crassifolium. High concentrations of bisabolol can also be found in certain medicinal cannabis cultivars. It is poorly soluble in water and glycerine, but soluble in ethanol. The enantiomer, α-(+)-bisabolol, is also found naturally but is rare. Synthetic bisabolol is usually a racemic mixture of the two, α-(±)-bisabolol. It is the terpenoid responsible for distinctive aroma of chamomile flowers, and when isolated, its scent has also has been likened to apples, sugar and honey. A structurally related compound known as β-bisabolol (CAS registry number [15352-77-9]) differs only in the position of the tertiary alcohol functional group.
Formula: C15H26O
Molar Mass: 222.372 g·mol−1
PubChem CID: 10586
Boiling Point: 153 °C (307 °F; 426 K) at 12 mmHg
Density: 0.92 g cm−3
Vapor Pressure: 0.015Pa at 20℃
FEMA: 4666 | ALPHA-BISABOLOL
Refractive Index: n20/D 1.496
Flash Point: 135 °C
Storage Temp: -20°C
PKA: 15.04±0.29(Predicted)
Form: Neat
Optical Activity: [α]/D -60±2°, neat
Water Solubility:: 22mg/L at 20℃